爱情帮你办分集剧情:查这种产品：Exendin-4（美国Sigma公司生产的）说明书

E7144
Sigma Exendin-4
≥97%
Amino Acid SequenceHis-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

Molecular FormulaC184H282N50O60S

Molecular Weight4186.57

CAS Number141758-74-9
MDL number MFCD00240171

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Descriptions

Other Notes Originally isolated from Heloderma suspectum (Gila monster lizard) venom.

Biochem/physiol Actions Exendin-4, a 39 amino acid peptide, activates GLP-1 (glucagon-like peptide-1) receptors to increase intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptors.

Properties

storage temp. −20°C
References

Reference Eng, J., et al., Isolation and characterization of exendin-4 an exendin-3 analogue from Heloderma suspectum venom. J. Biol. Chem. 267, 7402, (1992)

Singh, G., et al., Use of 125I-[Y39] exendin-4 to characterize exendin receptors on dispersed pancreatic acini and gastric chief cells from guinea pig. Regul. Pept. 53, 47, (1994)

Montrose-Rafizadeh, C., et al., High potency antagonists of the pancreatic glucagon-like peptide-1 receptor. J. Biol. Chem. 272, 21201-21206, (1997)

Beak, S.A., et al., Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line. J. Clin. Invest. 101, 1334-1341, (1998)
Related Categories

... Obesity Research > Exendin

... Toxins > Lizard

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